Repurposed Cancer Treatments

Off-patent drugs with anticancer evidence. Each gets an evidence grade based on the quality of human clinical data, not preclinical hype.

Treatment · 9 min read

Mebendazole for Lung Cancer

Phase I/II data in small cell lung cancer. Microtubule disruption mechanism, crosses blood-brain barrier.

🔬 Grade B: Promising
Treatment · 9 min read

Itraconazole for Lung Cancer

Phase II trial in NSCLC showing 72-79% tumor growth reduction in xenograft models. Hedgehog + VEGFR2 pathway inhibition.

🔬 Grade B: Promising
Treatment · 10 min read

Disulfiram (Antabuse) + Copper for Cancer

Phase II trials in GBM, breast, and pancreatic cancer. Cuproptosis mechanism discovered in 2022. Cancer stem cell elimination.

🔬 Grade B: Promising
Treatment · 12 min read

The Press-Pulse Protocol

Thomas Seyfried's metabolic framework targets both glucose and glutamine simultaneously. The most complete dietary-metabolic approach to cancer management.

🔬 Grade B: Promising
Treatment · 12 min read

High-Dose IV Vitamin C: The Trial That Doubled Survival

A Phase II RCT doubled overall survival in metastatic pancreatic cancer. We break down the Iowa trial, mechanism, and what it means.

⭐ Grade A: Strong Evidence
Treatment · 10 min read

Mebendazole: The $5 Cancer Drug

An FDA-approved dewormer with Phase I/II trial data in glioblastoma and colorectal cancer. Crosses the blood-brain barrier.

🔬 Grade B: Promising
Treatment · 9 min read

Quercetin for Cancer

Senolytic flavonoid that clears chemotherapy-induced senescent cells. D+Q combination in early human trials. Low oral bioavailability remains a problem.

🔶 Grade C: Early / Limited
Treatment · 9 min read

Mistletoe (Iscador) for Cancer

Used in German integrative oncology for decades. Quality of life benefits documented in RCTs. Survival benefit unproven but cohort studies are intriguing.

🔶 Grade C: Early / Limited
Treatment · 10 min read

CBD Oil for Cancer

Cannabidiol shows apoptosis, angiogenesis inhibition, and metastasis suppression in lab models. Human evidence is anecdotal. Grade C.

🔶 Grade C: Early / Limited
Treatment · 10 min read

Turkey Tail Mushroom and Cancer

PSK (polysaccharide-K) approved as cancer adjuvant in Japan since 1977. Cochrane review found significant survival benefit in GI cancers with chemotherapy.

🔬 Grade B: Promising
Treatment · 11 min read

Artemisinin for Cancer

Iron-dependent oxidative stress selectively toxic to cancer cells. Phase I/II trials show safety and early signal. One of the most compelling off-patent compounds.

🔬 Grade B: Promising