Repurposed Cancer Treatments

Off-patent drugs with anticancer evidence. Each gets an evidence grade based on the quality of human clinical data, not preclinical hype.

Treatment · 12 min read

High-Dose IV Vitamin C

Phase II RCT doubled survival in metastatic pancreatic cancer. Best human data of any repurposed compound.

⭐ Grade A: Strong Evidence
Treatment · 10 min read

Mebendazole

FDA-approved dewormer with Phase I/II data in glioblastoma and colorectal cancer. Crosses the blood-brain barrier. ~$5/course.

🔬 Grade B: Promising
Treatment · 9 min read

Itraconazole

Antifungal with Phase II data in prostate cancer and NSCLC. Multi-target: Hedgehog, angiogenesis, mTOR.

🔬 Grade B: Promising
Treatment · 10 min read

Disulfiram + Copper

Alcoholism drug + copper kills cancer stem cells via cuproptosis. JAMA RCT in glioblastoma.

🔬 Grade B: Promising
Treatment · 7 min read

Atovaquone

Antimalarial that reduces tumor hypoxia. Human PET-CT data confirms mechanism in NSCLC patients.

🔬 Grade B: Promising
Treatment · 8 min read

DCA (Dichloroacetate)

Reverses the Warburg effect. Phase I data in brain tumors. Cheap but limited by neuropathy.

🔶 Grade C: Early / Limited
Treatment · 9 min read

Fenbendazole

The Joe Tippens protocol dog dewormer. Viral story, real mechanism, but zero human trials. Mebendazole is the smarter bet.

🔶 Grade C: Early / Limited
Treatment · 8 min read

Ivermectin

Multi-target antiparasitic with impressive preclinical data. But can anticancer doses be safely achieved in humans?

🔶 Grade C: Early / Limited