The Anti-Cancer Protocol
An evidence-ranked stack of interventions from free (fasting, exercise, light discipline) to prescription-only (rapamycin). Updated as new trial data emerges.
The Core Logic
This stack works by hitting cancer through multiple mechanisms simultaneously: metabolic stress (fasting reduces IGF-1/insulin), detoxification induction (sulforaphane, Nrf2), cell cycle disruption (mebendazole), immune optimization (melatonin, vitamin D, exercise), and early detection (Galleri). The reason conventional medicine doesn't offer this isn't because it doesn't work. It's because none of it is patentable.
Daily
Overnight Fast: 13+ hours
🔬 Grade B: PromisingLast meal at 8pm, first meal at 9am+. Suppresses IGF-1, activates autophagy (cellular cleanup), and metabolically stresses cancer cells that can't switch fuel sources. Free, zero side effects.
Sulforaphane: Broccoli Sprouts or Supplement
🔬 Grade B: PromisingSmall handful of raw broccoli sprouts or standardized sulforaphane capsule. Activates Nrf2 detoxification pathways. Phase II RCT signal in prostate cancer. Must be raw: cooking destroys the myrosinase enzyme needed for activation.
Vitamin D3 3000-4000 IU + K2 100mcg
🔬 Grade B: PromisingVITAL trial (25,871 participants): no effect on cancer incidence, but 25% reduction in cancer mortality. Target serum level: 50-60 ng/mL, not just "normal" at 20. K2 (MK-7 form) directs calcium to bones, away from arteries.
Omega-3: 2g EPA+DHA
🔬 Grade B: PromisingVITAL trial also tested omega-3 (1g/day). Result: no effect on cancer incidence, but 40% reduction in fatal cancer. Reduces inflammatory prostaglandins that drive cancer progression. Fish oil or algae-based supplement.
Exercise: Zone 2 Cardio 4-5x/week + Resistance 2x/week
⭐ Grade A: Strong Evidence20-30% reduced risk of colon, breast, and endometrial cancers in active vs. sedentary. Mechanisms: reduces insulin/IGF-1, reduces adiposity, reduces inflammation, enhances immune surveillance. Zone 2 (conversational pace, 30-45 min) is optimal for metabolic effects.
Melatonin 10-20mg at bedtime (complete darkness)
🔬 Grade B: PromisingNot the sleep dose (1-3mg). The anticancer dose. Meta-analysis of 8 RCTs: 34% reduction in one-year cancer mortality. No lethal dose ever established. Start at 5mg and work up over 1-2 weeks. Night shift work suppresses melatonin — IARC Group 2A carcinogen.
Weekly
Mebendazole 100mg twice daily, 2-3 days per week
🔬 Grade B: PromisingTake with fatty food (absorption drops 70% without fat). FDA-approved antiparasitic with Phase I/II clinical trial data in glioblastoma and colorectal cancer. Disrupts microtubule polymerization in cancer cells, blocks glucose uptake, induces apoptosis, crosses the blood-brain barrier. $5-15/course.
Extended Fast 18-20 hours (once weekly)
🔶 Grade C: Early / LimitedPush the overnight fast to 18-20 hours once a week (skip breakfast, first meal at 1-2pm). Spikes autophagy more aggressively, crashes IGF-1, metabolically stresses cancer cells. Free, zero side effects beyond hunger.
Monthly
Fasting-Mimicking Diet: 5 days, ~800 kcal/day
🔶 Grade C: Early / LimitedHigh fat (40-50%), very low carb, low protein. Valter Longo's protocol (Prolon kit or DIY). Human pilot data shows significant IGF-1 reduction, immune system reset, and favorable cancer-risk metabolic markers. Cancer cells can't adapt as rapidly as normal cells.
Lab Tracking: IGF-1, hsCRP, Fasting Insulin, Vitamin D, A1C
⭐ Grade A: Strong EvidenceManage what you measure. High IGF-1 = elevated cancer risk. hsCRP > 1.0 = chronic inflammation. Fasting insulin > 5 = hyperinsulinemia. Target vitamin D at 50-60 ng/mL. These are the biological levers the protocol is trying to move.
Annual
Galleri Multi-Cancer Blood Test
⭐ Grade A: Strong EvidenceDetects 50+ cancer types from a blood draw using DNA methylation patterns. PATHFINDER 2 trial (25,578 participants): 7x cancer detection increase over standard screening alone. NHS-Galleri trial: 4-fold higher detection, substantial reduction in late-stage diagnoses. Stage I vs. Stage IV is often the difference between 95% and 10% five-year survival.
Advanced Layer (Physician-Assisted)
These require a prescription and medical oversight. More compelling biology with larger evidence gaps.
Rapamycin 5-10mg once weekly (off-label)
🔶 Grade C: Early / LimitedmTOR inhibition. Every animal aging model shows reduced cancer incidence and extended lifespan. Rapalogs are FDA-approved cancer drugs at high doses. Off-label pulsed low dosing (once weekly) is the longevity approach used by many physicians. No human cancer prevention RCT yet. Requires Rx and monitoring.
Disulfiram 250mg + Copper Gluconate 2mg (off-label)
🔬 Grade B: PromisingKills cancer stem cells via cuproptosis. Reverses multidrug resistance. JAMA Network Open RCT (2023) in glioblastoma showed safety. Active Phase I/II trials. Requires prescription and absolute alcohol avoidance (severe reaction with any alcohol).
Full Stack Summary
| Intervention | Grade | Risk | Monthly Cost |
|---|---|---|---|
| Overnight fasting 13h+ | B | Zero | Free |
| Exercise 150+ min/week | A | Zero | Free |
| Melatonin 10-20mg nightly | B | Essentially zero | ~$15 |
| Vitamin D3+K2 | B | Very low | ~$15 |
| Sulforaphane (sprouts) | B | Very low | ~$20 |
| Omega-3 2g EPA+DHA | B | Very low | ~$20 |
| Mebendazole 100mg 2-3x/week | B | Low | ~$15 (Rx) |
| FMD 5 days/month | C | Low | $0-50 |
| Galleri test (annual) | A | Zero | ~$80 annualized |
Medical Disclaimer: This protocol is a research synthesis for educational purposes. It is not medical advice and should not replace consultation with qualified healthcare professionals. Drug interactions, contraindications, and individual health factors matter. Discuss any changes to your health regimen with your doctor before starting.