All Research Reviews
Every article published on Cancer Prevention Lab, sorted by date.
The Galleri Test: Is $950/yr Worth It?
A blood test that detects 50 cancer types. PATHFINDER 2 trial showed 7x cancer detection. We analyze what that actually means.
⭐ Grade A: Strong EvidenceHigh-Dose Melatonin: The 34% Mortality Reduction
Meta-analysis of 8 RCTs shows melatonin at 10-20mg reduced cancer mortality by 34%. No toxicity ever established.
🔬 Grade B: PromisingHigh-Dose IV Vitamin C: The Trial That Doubled Survival
A Phase II RCT doubled overall survival in metastatic pancreatic cancer. We break down the Iowa trial, mechanism, and what it means.
⭐ Grade A: Strong EvidenceMebendazole: The $5 Cancer Drug
An FDA-approved dewormer with Phase I/II trial data in glioblastoma and colorectal cancer. Crosses the blood-brain barrier.
🔬 Grade B: PromisingSulforaphane: The Nrf2 Activator From Broccoli Sprouts
Activates detox pathways. Phase II RCT signal in prostate cancer. 20-100x more potent in sprouts than mature broccoli.
🔬 Grade B: PromisingItraconazole: The Antifungal With Cancer Data
Antifungal with Phase II data in prostate cancer and NSCLC. Multi-target: Hedgehog, angiogenesis, mTOR.
🔬 Grade B: PromisingVitamin D3: The VITAL Trial Explained
No effect on cancer incidence, but 25% reduction in cancer mortality. Why the target level matters more than dose.
🔬 Grade B: PromisingDisulfiram + Copper: The Alcoholism Drug That Kills Cancer Stem Cells
JAMA RCT in glioblastoma. Cuproptosis mechanism. Strong Phase II signal.
🔬 Grade B: PromisingAtovaquone: The Antimalarial That Reduces Tumor Hypoxia
Human PET-CT data confirms mechanism in NSCLC patients. Repurposed from malaria.
🔬 Grade B: PromisingExercise as Cancer Prevention
20-30% reduced risk of colon, breast, and endometrial cancers. One of the most consistent signals in prevention research.
⭐ Grade A: Strong EvidenceMetformin for Cancer: The Trial That Killed the Hypothesis
The MA.32 RCT (3,649 patients, JAMA 2022): HR 1.01. Absolutely no benefit. The observational data was biased.
⚠️ Grade D: Weak / MixedDCA (Dichloroacetate): The Warburg Effect Reverser
Reverses the Warburg effect. Phase I data in brain tumors. Cheap but limited by neuropathy.
🔶 Grade C: Early / LimitedFasting and Caloric Restriction
Reduces IGF-1 and insulin, activates autophagy. Animal data strong. Human data promising but limited.
🔶 Grade C: Early / LimitedFenbendazole: The Joe Tippens Protocol
The dog dewormer that went viral. Real mechanism, zero human trials. Mebendazole is the evidence-based alternative.
🔶 Grade C: Early / LimitedIvermectin: Multi-Target Antiparasitic
Impressive preclinical data across multiple cancers. But can anticancer doses be safely achieved in humans?
🔶 Grade C: Early / LimitedRapamycin for Cancer Prevention
mTOR inhibition: the most compelling biology with the biggest evidence gap. Prescribed off-label by longevity physicians.
🔶 Grade C: Early / LimitedAspirin for Colorectal Cancer
Real 10-19% risk reduction. But ASPREE trial complicated things for older adults. Age and timing matter.
🔬 Grade B: PromisingBPC-157: Wrong Direction for Cancer
Pro-angiogenic peptide that promotes the exact processes cancers exploit. Not anticancer. Potentially harmful.
❌ Grade DEBUNKED: DebunkedGcMAF: The Retracted Fraud
Key researcher's papers retracted. No credible evidence. Products sold online are unregulated and dangerous.
❌ Grade DEBUNKED: Debunked